The Oh Lab is interested in the fundamental mechanisms that drive the initiation, development, and progression of hematologic malignancies. We utilize patient samples as well as mouse models to investigate the pathogenesis of myeloproliferative neoplasms (MPNs) and secondary acute myeloid leukemia. A major focus of the lab is to utilize single cell mass cytometry to interrogate dysregulated cytokine-signaling networks in MPNs. In conjunction with these efforts we employ animal models to investigate the role of inflammatory cytokine signaling in MPN development in vivo. A second area of interest is the application of next-generation sequencing approaches to delineate genomic complexity and clonal evolution in MPNs. We also utilize patient-derived iPSCs and CRISPR gene editing to model human MPN pathogenesis. The long-term objective is to integrate these approaches and connect phenotype with underlying genotype. Ultimately, we seek to translate this work into improved therapies for MPN patients.